Well-designed in vitro simulation technologies offer a very useful alternative or complementary approach for human or animal studies. Being representative for specific processes, such models enable reproducible in-depth studies of these processes without ethical constraints. The easier setup and sampling allow medium to high throughput studies at lower costs offer the unique capacity to evaluate the mechanism of action of a specific compound. For this reason, ProDigest based its activities on the validated in vitro SHIME technology platform, which is internationally accepted as a representative simulation of the gastrointestinal tract and a valuable. The SHIME technology is combined with a broad array of complementary model systems and analysis techniques, making the ProDigest technology platform an essential tool for innovative product development. A crucial factor, which determines the relevance of using this extensive in vitro approach, is the question into what extent the obtained data may be translated to the human situation. All our models have therefore been extensively validated with animal and human studies.
Our offer
- Short-term in vitro experiments
- Simulator of Human Intestinal Microbial Ecosystem (SHIME)
- Absorption modelling
- Characterization of the microbial community activity and composition
- M-SHIME and related technologies
- Host response evaluation
- Strain characterization
- Dissolution studies
- Long-term development projects